apalutamide will minimize the level or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicine which can be CYP2C19 substrates can lead to decrease exposure to those medications.Diazepam is actually a Agenda IV managed substance